Ventilator-associated pneumonia with Col-S strains: a successful comeback of colistin!

AUTOR(ES)

Mukhopadhyay, C., Krishna, S., Vandana, K.E., Shenoy, A., Bairy, I.

FONTE

Brazilian Journal of Infectious Diseases

DATA DE PUBLICAÇÃO

2008-10

RESUMO

Emergence of multi and pan-drug resistant Gram-negative bacteria causing nosocomial infections in intensive care settings has become a challenge for clinicians. The mortality rate of ventilator-associated pneumonia (VAP) is known to increase when the initial microbiological diagnosis and antimicrobial therapy are inappropriate. We present a case of a 18-year-old man, who after being admitted following an accident, had developed VAP due to multi-drug resistant Pseudomonas aeruginosa and Acinetobacter spp. and had a downhill clinical course despite broad-spectrum antibiotic treatment. The strains were found to be Col-S, as the susceptibility was tested. Colistin was instituted, with remarkable recovery. It is imperative to diagnose VAP with multi-drug resistant strains as early as possible; colistin, the 'last resort' antibiotic, if instituted with proper monitoring at the right time, can be life saving.

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