VEGF-C e densidade de vasos linfáticos em carcinoma espinocelular de boca: associação com as metástases linfonodais ocultas e com o prognóstico dos pacientes / VEGF-C and lymphatic vessel density in oral squamous cell carcinoma: association with occult lymph node metastasis and patients prognosis

AUTOR(ES)

Simone Eloiza Sita Faustino

DATA DE PUBLICAÇÃO

2010

RESUMO

This study evaluated the lymphatic vesssel density (LVD) in correlation with the vascular endothelial growth factor-C (VEGF-C) expression by tumors cells and with clinical and pathological variables in patients with oral squamous cell carcinomas (OSCC). Eighty-seven patients with primary OSCC, clinically T1N0M0 or T2N0M0, with occult lymph-node metastases (pN+) and without (pN0), were analysed after treated in the A. C. Camargo Cancer Hospital, São Paulo, Brazil. Archived paraffin-embedded tumor specimens were sectioned and stained with anti- human podoplanin and VEGF-C antibodies. Lymphatic vessels were counted in intratumoral (ILVD) and peritumoral (PLVD) areas in twenty sequential high-power fields and in five hot spot high-power fields from each tumor. Average values were obtained and used as cutoff point. The correlations between ILVD/PLVD and VEGF-C expression as well as clinicopathological parameters were obtained by chi-square test or Fishers exact test. The 5 and 10-year survival rates were calculated by the Kaplan-Meier method and compared by log-rank test. No statistically significant difference was found between VEGF-C expression in OSCC in regard to clinicopathological parameters. An association between the ILVD and regional recurrence was found (p=0.047) and the PLVD showed associations with disease-specific survival (p=0.044) and disease-free survival (p=0.016). These findings indicate that high ILVD may influences the regional recurrence in neck lymph nodes of patients with early OSCC, however this data was not enough to influence the disease-free survival of these patients with a statistically significant association. PLVD or ILVD did not show predictive value for occult lymph-node metastases in the early stages of OSCC.

ASSUNTO(S)

carcinoma espinocelular lymphatic metastasis lymphatic vessels metástase linfática metástase neoplásica mouth neoplasms neoplasias bucais neoplasm metastasis prognosis prognóstico squamous cell carcinoma vasos linfáticos

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