Variantes do P21/WAF1 e da ciclina D1 e carcinoma de células escamosas de boca
AUTOR(ES)
Carolina Cavalieri Gomes
DATA DE PUBLICAÇÃO
2007
RESUMO
Genetic factors are known to be involved in oral squamous cell carcinoma (OSCC) development. We evaluated a possible association between CCND1 G870A and P21 C98A polymorphisms in OSCC, as well as the impact of the genotypes on protein immunoexpression. No statistical association between CCND1 and/or P21 genotypes in OSCC was demonstrated, although we found that people harboring the combined presence of at least one variant allele of both genes showed a 1.8 times more chance of developing OSCC compared to the referent genotype. OSCC tumours from individuals with P21 heterozygous genotype showed a significantly higher immunopositivity than tumours from wild-type individuals, demonstrating that P21 protein expression in OSCC is affected by P21/WAF1 genotype.
ASSUNTO(S)
carcinoma de células escamosas teses. boca cancer citopatologia teses. boca câncer teses.
ACESSO AO ARTIGO
http://hdl.handle.net/1843/ZMRO-6ZXMRYDocumentos Relacionados
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