Valores de referência de acetona urinária em uma população do sul de Minas Gerais / Reference values for urinary acetone in a population of south of Minas Gerais state

AUTOR(ES)
DATA DE PUBLICAÇÃO

2002

RESUMO

The determination of reference values of some xenobiotics is important for the biomonitoring, to compare the concentration in the exposed and the general population. The acetone is a very popular solvent, that is used in a large number of industries and laboratories. Isopropanol is used in industries, laboratories and cosmetic products. In the human body, this solvent is metabolized and the most important product is acetone. Acetone in urine (AcU) is the most used biomarker to monitore workers exposed to acetone/isopropanol. This substance is also found in non-exposed people, so, the main objective of this work was to verify the basal levels of AcU and if there are some factors that have influence on these levels. 207 volunteers were studied (91 men and 116 women, and the ages between 18-80 years). The AcU was determinated by headspace/gas chromatography/ FID. The method showed linearity between 0.1-5.0 mg/L; limit of detection (LOD) and limit of quantification of 0.1 mglL; intra-assay precision, between 4 and 5%; inter-assay precision, between 5.2 and 8.8% (urine without addition, and spiked 1.0 and 3.0 mg/L of acetone). In the total population, the reference values obtained were: mean (±SD) 1.12 (± 0.47) mg/L; median 1.04 mg/L; geometric mean 1.03 mg/L; 95% confidence range between 0.98-1.26 mg/L and upper reference value (mean + 2 SD) of 2.06 mg/L. The values distribution wasnt "normal", therefore, the ,transformation of the values was necessary (109 AcU). Sex and alcohol intake showed significant influence on the concentration of acetone in urine. No interference was verified for smoking or the age of the volunteers.

ASSUNTO(S)

valores de referência isopropanol reference values urine urina biomonitorização acetona acetone isopropanol biomonitoring

ACESSO AO ARTIGO

Documentos Relacionados