"Valor prognóstico e preditivo da expressão imunoistoquímica de timidilato sintase em pacientes portadores de adenocarcinoma colorretal" / Prognostic and predictive value of the immunohistochemical expression of thymidylate synthase in patients with colorectal carcinoma

AUTOR(ES)
DATA DE PUBLICAÇÃO

2004

RESUMO

The purpose of this study was trying to assess the value of TS expression as a predictive factor in the efficacy of adjuvant chemotherapy in colorectal cancer, as well as its independent prognostic value for survival. It deals with a retrospective study that assesses a series of 114 individuals with high risk colorectal cancer, distributed into two different groups: 1)surgery alone (n=61); 2)surgery and 5-FU-based chemotherapy (n=53). TS expression was determined by immunohistochemistry. We observed that TS expression may select patients that benefit from adjuvant chemotherapy, but it was not shown as an independent variable for the risk of recurrence or death

ASSUNTO(S)

fluoruracila/uso terapêutico retrospective studies estudos retrospectivos prognosis timidilato sintase chemotherapy adjuvant/methods thymidylate synthase prognÓstico fluorouracil//therapeutic use imunohistoquÍmica/métodos quimioterapia adjuvante/métodos colorectal neoplasms/drug therapy immunohistochemistry/methods neoplasias colorretais/quimioterapia

ACESSO AO ARTIGO

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