Vaccinia virus preferentially enters polarized epithelial cells through the basolateral surface.
AUTOR(ES)
Rodriguez, D
RESUMO
The uptake of vaccinia virus in polarized epithelial cells was studied to determine whether the site of entry was confined to either the apical or the basolateral membrane. Virus infection was monitored with a recombinant vaccinia virus carrying the luciferase reporter gene. Using cell lines MDCK and MDCK-D11, a clonal line with high transepithelial electrical resistance, we determined that vaccinia virus preferentially enters through the basolateral membrane. The possibility that there is a polarized cell surface distribution of vaccinia virus receptors which may be involved in systemic poxvirus infections is discussed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=240545Documentos Relacionados
- Shigella flexneri enters human colonic Caco-2 epithelial cells through the basolateral pole.
- Basolateral maturation of retroviruses in polarized epithelial cells.
- RalA but Not RalB Enhances Polarized Delivery of Membrane Proteins to the Basolateral Surface of Epithelial Cells
- Expression of the human immunodeficiency virus envelope glycoprotein is restricted to basolateral surfaces of polarized epithelial cells.
- Measles Virus Preferentially Transduces the Basolateral Surface of Well-Differentiated Human Airway Epithelia
