Use of a Snake Venom Toxin to Characterize the Cholinergic Receptor Protein*
AUTOR(ES)
Changeux, Jean-Pierre
RESUMO
α-Bungarotoxin, a polypeptide of mol wt 8000 purified from the venom of Bungarus multicinctus, blocks irreversibly and specifically the excitation by cholinergic agonists on the isolated electroplax and on purified membrane fragments in vitro. The toxin also blocks the in vitro binding of decamethonium to a protein recently isolated from electric tissue. This observation strengthens our earlier conclusion that this protein is the cholinergic receptor macromolecule.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=283343Documentos Relacionados
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- SNAKE VENOM CONJUNCTIVITIS*