Use and limitations of peripheral tolerance in experimental model of asthma / Uso e limitações da tolerância imunológica periférica em modelo de asma experimental

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

Mucosal administration of soluble Ags, before the sensitization with the same Ag, leads to mucosal tolerance. We studied the effect of i.n. LPS during the induction of ovalbumin (OVA) nasal tolerance. The majority of murine models of asthma used OVA as allergen,thus, we also used Blomia tropicalis (Bt) extract, a mite more common in asthmatic patients. Features of Bt block the nasal tolerance establishment and experimental data indicates that tolerance towards an Ag can promote tolerance to another not related Ag (cross-tolerance). Therefore, we evaluated if OVA or hen-egg white lisozyme (HEL) tolerance could result in cross-tolerance to the Bt. Our data showed that i.n. LPS during induction of tolerance to OVA prevents the establishment of this tolerance, resulting in neutrophil migration, IgG2a production, decreased levels of IgE and increased anaphylactic IgG1. We verify that nasal tolerance to HEL or OVA is not capable in induce cross-tolerance against the Bt. We also observed that OVA oral tolerance is able to induce cross-tolerance against Bt.

ASSUNTO(S)

lipopolysaccharides cross-tolerance tolerância imunológica blomia tropicalis blomia tropicalis ovalbumina asma experimental lipopolissacarídeos immunological tolerance torância cruzada ovoalbunima experimental asthma

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