Urinary Side Effects of Duloxetine in the Treatment of Depression and Stress Urinary Incontinence

AUTOR(ES)

Viktrup, Lars

FONTE

Physicians Postgraduate Press

RESUMO

Background: The efficacy and safety of duloxetine, a dual reuptake inhibitor of serotonin and norepinephrine at the recommended starting dose, have been demonstrated in the treatment of major depressive disorder (MDD) in men and women and in the treatment of stress urinary incontinence (SUI) in women. Since the mechanism of action of duloxetine in the treatment of SUI is believed to be related to enhanced urethral closure forces, it is important to clarify the risk of acute urinary retention.

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