Urinary hippuric acid concentration after occupational exposure to toluene.
AUTOR(ES)
Wilczok, T
RESUMO
The results of industrial investigations have shown a correlation between the rate of hippuric acid excretion in a single urine sample collected after daily occupational exposure and the amount of toluene absorbed. The rate of hippuric acid excretion and the average concentration of toluene vapour during exposure time were also related. The quantitative range of the test has been limited to amounts exceeding 425 mg of toluene and concentrations exceeding 69 ppm of toluene in the air because of the physiological presence of hippuric acid in urine. The rate of hippuric acid excretion in urine depends on diuresis and is constant for urinary fractions with diuresis of 30 ml/h. The physiological excretion rate was 20 mg/h with a standard deviation +/- 4.3 mg/h, maximal physiological level 33 mg/h.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1008450Documentos Relacionados
- Urinary hippuric acid and orthocresol excretion in man during experimental exposure to toluene.
- Toxicokinetics of toluene and urinary excretion of hippuric acid after human exposure to 2H8-toluene.
- Antipyrine clearance during experimental and occupational exposure to toluene.
- Significance of urinary hippuric acid determination as an index of toluene exposure
- Measurement by gas chromatography of urinary hippuric acid and methylhippuric acid as indices of toluene and xylene exposure.
