Urinary 2,5-hexanedione in workers exposed to n-hexane: influence of the sample treatment
AUTOR(ES)
Nolasco, Daniela Magalhães, Gusmão, Andréia, Siqueira, Maria Elisa Pereira Bastos de
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2007-08
RESUMO
The aim of the present study was to determine 2,5-hexanedione (2,5-HD), a metabolite of n-hexane, by gas chromatography/flame ionization detection in 31 workers exposed to n-hexane after two types of sample pretreatment, i.e., with (total 2,5-HD) and without (free 2,5-HD) acid hydrolysis. The mean urinary 2,5-HD was 0.52 mg/L (free) and 2.88 mg/L (total), this difference being significant (Student t-test, p < 0.05). The differences in the results according to the sample treatment support the need to modify the current Brazilian legislation, which proposes the analysis of 2,5-HD without indicating whether it is the free or total metabolite.
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