Upregulation of hsa-miR-125b in HTLV-1 asymptomatic carriers and HTLV-1-associated myelopathy/tropical spastic paraparesis patients

AUTOR(ES)

Nicolete, Larissa Deadame de Figueiredo, Nicolete, Roberto, Haddad, Rodrigo, Azevedo, Rochele, Castro, Fabíola Attié de, Tanaka, Yuetsu, Takayanagui, Osvaldo Massaiti, Covas, Dimas Tadeu, Kashima, Simone

FONTE

Mem. Inst. Oswaldo Cruz

DATA DE PUBLICAÇÃO

2012-09

RESUMO

The retrovirus human T lymphotropic virus type 1 (HTLV-1) promotes spastic paraparesis, adult T cell leukaemia and other diseases. Recently, some human microRNAs (miRNAs) have been described as important factors in host-virus interactions. This study compared miRNA expression in control individuals, asymptomatic HTLV-1 carriers and HTLV-1 associated myelopathy (HAM)/tropical spastic paraparesis patients. The proviral load and Tax protein expression were measured in order to characterize the patients. hsa-miR-125b expression was significantly higher in patients than in controls (p = 0.0285) or in the HAM group (p = 0.0312). Therefore, our findings suggest that miR-125b expression can be used to elucidate the mechanisms of viral replication and pathogenic processes.

Documentos Relacionados

• Center of gravity oscillations in HTLV-1-associated myelopathy/tropical spastic paraparesis
• High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1
• Clinical and laboratory features of HTLV-I asymptomatic carriers and patients with HTLV-I-associated myelopathy/tropical spastic paraparesis from the Brazilian Amazon
• Proprioceptive neuromuscular facilitation in HTLV-I-associated myelopathy/tropical spastic paraparesis
• The Role of Human T-Lymphotropic Virus Type 1 (HTLV-1)-Infected Dendritic Cells in the Development of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis