UNSATURATED AMINO ACIDS V. : Microbiological Properties of Some Halogenated Olefinic Amino Acids1

AUTOR(ES)

Shapira, Jacob

RESUMO

Shapira, Jacob (Department of Chemistry, Florida State University, Tallahassee) and Karl Dittmer. Unsaturated amino acids. V. Microbiological properties of some halogenated olefinic amino acids. J. Bacteriol. 82:640–647. 1961.—It has been shown previously that several amino acid analogues containing unsaturated linkages were inhibitors of the growth of Escherichia coli and Saccharomyces cerevisiae. This paper reports the results obtained when a series of unsaturated halogen-containing amino acids was examined. The cis isomer of ω-chloroallylglycine showed the greatest toxicity yet found in this series of unsaturated amino acids toward E. coli, whereas the trans-isomer was usually far less toxic. The major effect of cis-ω-chloroallylglycine in E. coli appeared to be to extend the lag phase before the normal rate of growth began. A wide variety of amino acids was capable of partially or completely preventing the toxicity of low levels of these compounds. At higher levels, relatively few amino acids (primarily valine, leucine, and glutamic acid) were effective. In E. coli, cis-ω-chloroallylglycine showed an unusual [Formula: see text] relationship with both glutamic acid and valine over a wide range in concentration.

Documentos Relacionados

• METABOLISM OF ω-AMINO ACIDS V. : Energetics of the γ-Aminobutyrate Fermentation by Clostridium aminobutyricum1
• INDUCTION OF MORPHOLOGICAL ABERRATIONS IN RHODOSPIRILLUM RUBRUM BY d-AMINO ACIDS1
• STUDIES ON THE METABOLISM OF MYCOBACTERIUM TUBERCULOSIS V. : The Effect of Amino Acids on the Growth of M. tuberculosis var. hominis1
• Utilization of Inorganic Sulfate by Rumen Microorganisms: I. Incorporation of Inorganic Sulfate into Amino Acids1
• Inhibition of N2 Fixation in Soybean Is Associated with Elevated Ureides and Amino Acids1