Uncommon vancomycin: induced side effects

AUTOR(ES)

Rocha, Jaime Luís Lopes, Kondo, William, Baptista, Maria Inêz Domingues Kuchiki, Cunha, Clovis Arns da, Martins, Luzilma Terezinha Flenik

FONTE

Brazilian Journal of Infectious Diseases

DATA DE PUBLICAÇÃO

2002-08

RESUMO

Vancomycin has been used with increased frequency during the past 15 years and the most common toxicity with this drug is the "red man syndrome". Other adverse effects include neutropenia, fever, phlebitis, nephrotoxicity, ototoxicity, thrombocytopenia, interstitial nephritis, lacrimation, linear IgA bullous dermatosis, necrotizing cutaneous vasculitis and toxic epidermal necrolysis. Only two cases of vancomycin-induced Stevens-Johnson syndrome and one case of pancytopenia have been reported in the medical literature. The treatment for both situations is based on cessation of the vancomycin therapy; in cases of Stevens-Johnson syndrome, antihistamine and/or steroid agents can be used. This article reports a case of pancytopenia and a case of erythema major associated with neutropenia.

Documentos Relacionados

• Pharmacokinetics of vancomycin: observations in 28 patients and dosage recommendations.
• Vancomycin: the need to suit serum concentrations in hemodialysis patients
• Drug-Induced Ocular Side Effects and Drug Interactions
• Steroid-refractory ulcerative colitis treated with corticosteroids, metronidazole and vancomycin: a case report
• Prophylaxis against non-steroidal induced upper gastrointestinal side effects.