Um estudo quimico da Artemisia annua L. aclimatada no Brasil

AUTOR(ES)
DATA DE PUBLICAÇÃO

1996

RESUMO

The Asteracea Artemisia annua L. native of the Asian continent is well known for the production of a potent antimalarial compound, artemisinine 13. The purpose of this work was to study some chemical aspects of the plant adapted to Brazilian climate. The total hydrogen and carbon-13 NMR assigment of compounds 12, 21, 22 and 30 isolated from Artemisia annua L. as well as that of compounds 112, 113 and 114, obtained through chemical transformations,.are reported. The conformations and conformational equilibria of these compounds in solution which possess a cis-decalin moiety were obtained from spectral data and molecular mechanics calculations. The identification of the essential oil of the plant cultivated in Brazil was studied using GC/MS (HP 5890/HP 5970). Forty nine constituents were determined by association of retention time data and co-injection of authentic standards. Compound 125 is a new carbon skeleton not published up to this date. Comparison of the gas chromatography profile of the Artemisia annua L. essential oil produced in Brazil with those of other origins revealed significant variation of their constituinets. The seasonal behavior of artemisinine 13 content versus essential oil production was observed during one harvest period. The economical viability of several purification methologies for artemisinine production were tested. In this work we produced the antimalarial compound 13 at a total cost of US$ 11,5 per gram.

ASSUNTO(S)

essencias e oleos essenciais artemisia

ACESSO AO ARTIGO

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