Ultrastructural and immunohistochemical studies of the uterine stroma in the decorin-deficient mice during pregnancy. / Estudo ultraestrutural e imunohistoquímico do estroma uterino durante a gestação de camundongos deficientes em decorim.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

The present study is an ultrastructural investigation into the organization of collagen fibrils in the pregnant endometrium of wild-type and decorin-deficient mice. Our results showed that collagen fibrils from both genotypes present a great variability of shape and size in cross section. Significant variation in the diameter of collagen fibrils exists in the decidualized endometrium from both groups of animals. In the decidualized endometrium, the diameter of collagen fibrils increases in both genotypes were higher in Dcn-/- than in Dcn+/+ animals. In the Dcn-/- animals the percentage of thin fibrils with diameter is also higher, when compared with Dcn+/+ animals. We also showed that Bgn is expressed in the non decidualized endometrium in the Dcn-/- animals, on day 3 of pregnancy. The expression of lumican showed a very sharp labeling in the decidualized stroma from day 7, and in the non decidualized estroma from Dcn-/- animals. These results suggest that the deficience of decorin may play a role on collagen fibrillogenesis in different stages of pregnancy.

ASSUNTO(S)

decidua decorim ultrastructural endométrio endometrium knockout mice colágeno ultraestrutura collagen decídua camundongos nocautes decorim

ACESSO AO ARTIGO

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