Ultraconserved long non-coding RNA uc.112 is highly expressed in childhood T versus B-cell acute lymphoblastic leukemia

AUTOR(ES)

Chagas, Pablo Ferreira das; Sousa, Graziella Ribeiro de; Kodama, Márcio Hideki; Biagi Junior, Carlos Alberto Oliveira de; Yunes, José Andres; Brandalise, Silvia Regina; Calin, George Adrian; Tone, Luiz Gonzaga; Scrideli, Carlos Alberto; Oliveira, Jaqueline Carvalho de

FONTE

Hematol., Transfus. Cell Ther.

DATA DE PUBLICAÇÃO

2021-03

RESUMO

ABSTRACT Aberrant expression of long non-coding RNAs (lncRNAs) has been detected in several types of cancer, including acute lymphoblastic leukemia (ALL), but lncRNA mapped on transcribed ultraconserved regions (T-UCRs) are little explored. The T-UCRs uc.112, uc.122, uc.160 and uc.262 were evaluated by quantitative real-time PCR in bone marrow samples from children with T-ALL (n = 32) and common-ALL/pre-B ALL (n = 30). In pediatric ALL, higher expression levels of uc.112 were found in patients with T-ALL, compared to patients with B-ALL. T-cells did not differ significantly from B-cells regarding uc.112 expression in non-tumor precursors from public data. Additionally, among B-ALL patients, uc.112 was also found to be increased in patients with hyperdiploidy, compared to other karyotype results. The uc.122, uc.160, and uc.262 were not associated with biological or clinical features. These findings suggest a potential role of uc.112 in pediatric ALL and emphasize the need for further investigation of T-UCR in pediatric ALL.

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