Type III Secretion: a Virulence Factor Delivery System Essential for the Pathogenicity of Burkholderia mallei

AUTOR(ES)

Ulrich, Ricky L.

FONTE

American Society for Microbiology

RESUMO

By creating mutations in the Burkholderia mallei ATCC 23344 animal pathogen-like type III secretion system (TTSS), this study analyzes the correlation between type III secretion and the pathogenicity of ATCC 23344 in vivo. Mutagenesis demonstrated that a functional TTSS was required for the full pathogenicity of ATCC 23344 in the BALB/c mouse and Syrian hamster models of infection. However, vaccination with each mutant failed to elicit a protective immunity against challenge with wild-type ATCC 23344.

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