Two new diterpenoids from Leonurus japonicus

AUTOR(ES)

Wu, Hankui, Wang, Sensheng, Liu, Haijuan, E, Yan, Li, Yan, Liu, Ruijin, Wang, Jinjin, Xu, Zhiyong, Lv, Yanyan, Sun, Shanshan, Li, Gang, Shi, Yunfeng

FONTE

Rev. bras. farmacogn.

DATA DE PUBLICAÇÃO

2015-04

RESUMO

Abstract Two new labdane-type diterpenoids, 5-ethoxy-3-(2-((R)-4-hydroxy-2,5,5,8a-tetramethyl-3-oxo-3,5,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)furan-2(5H)-one (1), and 5-hydroxy-4-(2-((1R,3S,7aS)-1-hydroxy-4,4,7a-trimethyl-3-propionyloctahydroisobenzofuran-1-yl)ethyl)furan-2(5H)-one (2), were isolated from the EtOH extract of the herb of Leonurus japonicus Houtt., Lamiaceae. Their chemical structures were determined by analysis of 1D, 2D NMR, HRESIMS, and by comparison with known analogs.

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