Turnover of lymphocytes and conceptual paradigms in HIV infection

AUTOR(ES)

Silvestri, Guido

FONTE

American Society for Clinical Investigation

RESUMO

Prevailing views concerning the pathogenic mechanisms of AIDS have shifted from models that focus primarily on direct HIV-mediated killing of CD4+ T cells to models that emphasize the pathogenic role of generalized immune system activation. The observation that increases in T cell turnover seen in HIV-infected individuals primarily reflect increased proliferation of effector-memory T cells supports the concept that chronic immune activation plays a prominent, if not predominant, role in the pathogenesis of AIDS.

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