Tumorigenesis in mice carrying a truncating Brca1 mutation
AUTOR(ES)
Ludwig, Thomas
FONTE
Cold Spring Harbor Laboratory Press
RESUMO
We generated mouse mutants carrying in the Brca1 locus a modification (Brca1tr) that eliminates the C-terminal half of the protein product and obtained results indicating that, depending on genetic background, the missing BRCT and/or other domains are dispensable for survival, but essential for tumor suppression. Most of the apparently hypomorphic Brca1tr/tr mutants developed various tumors. Lymphomas were detected at all ages, whereas sarcomas and carcinomas, including breast cancer, appeared after a long latency. The mammary tumors showed striking variability in histopathological patterns suggesting stochastic engagement of tumorigenic pathways in their progression, to which the Brca1tr/tr mutation was apparently a late participant.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=313794Documentos Relacionados
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