TT Virus in the Nasal Secretions of Children with Acute Respiratory Diseases: Relations to Viremia and Disease Severity
AUTOR(ES)
Maggi, Fabrizio
FONTE
American Society for Microbiology
RESUMO
The natural history and pathogenic potential of the recently identified TT virus (TTV) are currently a matter of intensive investigation. In an attempt to shed some light on these issues, nasal and blood specimens of 1- to 24-month-old children hospitalized with a clinical diagnosis of acute respiratory disease (ARD) were examined for the presence, load, and genetic characteristics of TTV. The results have indicated that at least in young children, the respiratory tract not only represents a route by which abundant TTV can be shed into the environment but also may be a site of primary infection and continual replication. Although we found no compelling evidence that TTV was the direct cause of ARD in some of the children studied, the average loads of TTV were considerably higher in patients with bronchopneumonia (BP) than in those with milder ARD, raising interesting questions about the pathophysiological significance of TTV at this site. Furthermore, group 4 TTV was detected almost exclusively in children with BP.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=141071Documentos Relacionados
- TT Virus Loads and Lymphocyte Subpopulations in Children with Acute Respiratory Diseases
- STUDIES UPON THE NASAL SECRETIONS. I. THE CELLULAR CONTENT OF THE NASAL SECRETIONS IN ACUTE DISEASE OF THE RESPIRATORY TRACT
- Studies on Respiratory Diseases: Some Relations Between Extracts, Filtrates and Virulence of Pneumococci 1
- Cell-free and cell-bound antibody in nasal secretions from infants with respiratory syncytial virus infection.
- Antibody response to respiratory syncytial virus structural proteins in children with acute respiratory syncytial virus infection.