Trypanossoma cruzi: diversity, phylogenetics analysis and ecogeographic patterns of wild isolates. / Trypanosoma cruzi: diversidade, relações filogenéticas e padrões ecogeográficos de isolados silvestres.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

T. cruzi comprises highly heterogeneous populations classified as TCI and TCIIa-e lineages. This study characterized large wild mammal and vector strains of various geographical origins, and human isolates from Amazonia. Phylogenetic analysis using SSU rDNA and Cyb genes inferred relationships among lineages and their biogeographic patterns. ITS1 rDNA and RAPD detected intraspecific polymorphism. TCIIa circulates in primates in the Brazilian Amazon, transmitted by Rhodnius in arboreal ecotopes sporadically infecting humans. TCI is the most prevalent in the Amazonian primates and humans, and can induce severe Chagas disease as demonstrated in a patient from Northeast Brazil. Bats of several biomes were found infected by three trypanosome species, including a new lineage of T. cruzi denominated TCbat. Isolates from monkeys and bats were also molecularly characterized. The lineage TCIIc showed to be widespread in Brazil, and was associated to terrestrial mammals and triatomines. TCIIa from the USA corresponds to an independent lineage, probably absent in Brazil.

ASSUNTO(S)

ecotopes trypanossoma cruzi ecótopos mamíferos silvestres linhagens trypanossoma cruzi wild mammals triatomíneos triatomines phylogeny filogenia lineages

ACESSO AO ARTIGO

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