Trovafloxacin in treatment of rabbits with experimental meningitis caused by high-level penicillin-resistant Streptococcus pneumoniae.
AUTOR(ES)
Kim, Y S
RESUMO
The fluoroquinolone trovafloxacin was bactericidal (0.47 +/- 0.23 delta log10 CFU/ml x h after 10 mg/kg of body weight and 0.78 +/- 0.15 delta log10 CFU/ml x h after 30 mg/kg) in the treatment of experimental meningitis caused by a highly penicillin-resistant (MIC and minimum bactericidal concentration = 4 and 4 microg/ml) strain of Streptococcus pneumoniae. Combinations with ampicillin and rifampin were indifferent compared to single drugs.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=163879Documentos Relacionados
- Management of meningitis caused by penicillin-resistant Streptococcus pneumoniae.
- Management of meningitis caused by penicillin-resistant Streptococcus pneumoniae.
- Treatment of experimental endocarditis due to penicillin-resistant Streptococcus pneumoniae.
- Penicillin-resistant viridans streptococci have obtained altered penicillin-binding protein genes from penicillin-resistant strains of Streptococcus pneumoniae.
- Alterations in kinetic properties of penicillin-binding proteins of penicillin-resistant Streptococcus pneumoniae.
