Trophoblast gene expression: Transcription factors in the specification of early trophoblast
AUTOR(ES)
Roberts, R Michael
FONTE
BioMed Central
RESUMO
A zone of trophoblast specification is established when the embryo is a morula, presumably reflecting a unique combination of transcription factors in that zone of cells and the influence of various environmental cues and growth factors on them. A key first step in this process of specification is the down-regulation of Oct4, a transcription factor that acts as a negative regulator of trophoblast specification and of genes normally up-regulated as the trophectoderm first forms. The transcription factors believed to have a positive association with trophectoderm specification have been inferred primarily in two ways: by their expression patterns in embryos, ES cells and TS cells and by the consequences of gene disruption on embryonic development. Many of these transcription factors also control the expression of genes characteristically expressed in trophoblast but not in the epiblast, primitive endoderm and their derivatives. ES and TS cells from the mouse and other species are beginning to provide insights into the changes in gene expression that accompany lineage specification and the subsequent post-specification events that lead to functional trophoblast derivatives.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=471566Documentos Relacionados
- Baculovirus gp64 gene expression: analysis of sequences modulating early transcription and transactivation by IE1.
- Control of bacteriophage P2 gene expression: analysis of transcription of the ogr gene.
- Chromatin control of gene expression: Mixed-lineage leukemia methyltransferase SETs the stage for transcription
- On the Regulation of Gene Expression: Incompatibility in Schizophyllum
- Alternative pathway for induction of human immunodeficiency virus gene expression: involvement of the general transcription machinery.