Trisomy 21 with 47,+18 lymphocyte cell line: double mitotic nondisjunction.

AUTOR(ES)

Jenkins, M B

RESUMO

A patient with Down's syndrome was found to have 47,XX,+18/47,XX,+21 mosaicism. Chromosome 18 trisomy was found only in 18% of lymphocytes and not in skin fibroblasts. A likely interpretation is double nondisjunction in a single lymphocyte precursor of a trisomy 21 embryo. A brief review of other cases of mitotic multiple nondisjunction and double aneuploid mosiacism is presented.

Documentos Relacionados

• Segregation of recessive phenotypes in somatic cell hybrids: role of mitotic recombination, gene inactivation, and chromosome nondisjunction.
• Trisomy 18 with karyotype 47,XX,-18,+i psu dic(18p).
• 47,XX,+der(18),t(9;18)(p24;q21) mat: a distinct partial trisomy 18q--syndrome?
• H-2 hemizygous mutants from a heterozygous cell line: role of mitotic recombination.
• Partial trisomy 18 in a family with a translocation (18;21)(q21;q22).