Triorganotin as a compound with potential reproductive toxicity in mammals

AUTOR(ES)

Delgado Filho, V.S., Lopes, P.F.I., Podratz, P.L., Graceli, J.B.

FONTE

Brazilian Journal of Medical and Biological Research

DATA DE PUBLICAÇÃO

2011-09

RESUMO

Organotin compounds are typical environmental contaminants and suspected endocrine-disrupting substances, which cause irreversible sexual abnormality in female mollusks, called "imposex". However, little is known about the capability of triorganotin compounds, such as tributyltin and triphenyltin, to cause disorders in the sexual development and reproductive functions of mammals, including humans and rodents. Moreover, these compounds can act as potential competitive inhibitors of aromatase enzyme and other steroidogenic enzymes, affecting the reproductive capacity of male and female mammals. In this review, we discuss the cellular, biochemical, and molecular mechanisms by which triorganotin compounds induce adverse effects in the mammalian reproductive function.

Documentos Relacionados

• Male Reproductive Toxicity
• Experimental chemotherapy-induced skin necrosis in swine. Mechanistic studies of anthracycline antibiotic toxicity and protection with a radical dimer compound.
• Positive Darwinian selection drives the evolution of several female reproductive proteins in mammals
• Borocaptate sodium: a potential boron delivery compound for boron neutron capture therapy evaluated in dogs with spontaneous intracranial tumors.
• Human sensory nerve compound action potential amplitude: variation with sex and finger circumference.