Triglyceride accumulation protects against fatty acid-induced lipotoxicity

AUTOR(ES)

Listenberger, Laura L.

FONTE

The National Academy of Sciences

RESUMO

Excess lipid accumulation in non-adipose tissues is associated with insulin resistance, pancreatic β-cell apoptosis and heart failure. Here, we demonstrate in cultured cells that the relative toxicity of two common dietary long chain fatty acids is related to channeling of these lipids to distinct cellular metabolic fates. Oleic acid supplementation leads to triglyceride accumulation and is well tolerated, whereas excess palmitic acid is poorly incorporated into triglyceride and causes apoptosis. Unsaturated fatty acids rescue palmitate-induced apoptosis by channeling palmitate into triglyceride pools and away from pathways leading to apoptosis. Moreover, in the setting of impaired triglyceride synthesis, oleate induces lipotoxicity. Our findings support a model of cellular lipid metabolism in which unsaturated fatty acids serve a protective function against lipotoxicity though promotion of triglyceride accumulation.

Documentos Relacionados

• Cellular bicarbonate protects rat duodenal mucosa from acid-induced injury
• Mechanisms of fatty acid-induced inhibition of glucose uptake.
• Mechanism of free fatty acid-induced insulin resistance in humans.
• The Mechanism of Abscisic Acid-induced Proline Accumulation in Barley Leaves
• Inhibiting gluconeogenesis prevents fatty acid-induced increases in endogenous glucose production