Treatment of intrabony defects with ABM/P-15 or GTR in patientes with agressive periodontitis: a Clinical, Radiographic and gingival fluid cytokines levels evaluation / Avaliação do uso de matriz óssea bovina inorgânica associada ao peptídeo de adesão celular no tratamento de defeitos infra-ósseos em pacientes com periodontite agressiva. Estudo clínico, radiográfico e laboratorial em humanos

AUTOR(ES)

Adriana Corrêa de Queiroz

DATA DE PUBLICAÇÃO

2009

RESUMO

Background: Intrabony periodontal defects present a particular treatment problem, especially in patients with Generalized Aggressive Periodontitis (G-AgP).Researches have been performed in order to improve the results of regenerative procedures. Material and Methods: The aim of this study was to compare outcomes of intrabony periodontal defects following treatment with anorganic bone matrix/cell binding peptide (ABM/P-15) to guided tissue regeneration (GTR) in patients with GAgP. Fifteen patients, with two infrabony defects ≥3 mm deep, were selected for the present study. Patients were allocated randomly to be treated with ABM/P-15 or GTR. At baseline and at 6 months after surgery, clinical and radiographic parameters and IL-1β and IL-6 gingival fluid concentrations were recorded. Results: There was a significant PD reduction (P<0.001) for both groups (2.27±0.96 mm for ABM/P-15 group and 2.57±1.06 mm for GTR group) A CAL gain (1.87±0.94 mm for ABM/P-15 group and 2.09±0.88 mm for GTR group) was observed. In between-group comparisons, there were no statistical significant differences in clinical parameters. The radiographic bone fill was more expressive in ABM/P-15 group (2.49 mm) than in GTR group (0.73 mm). In subtraction radiographs, the areas representing gain in density were 93.16% of the baseline defect for ABM/P-15 group versus 62.03% in GRT group. There were no statiscally significant differences in between and intra-group comparison with regard to IL-1β and IL-6 quantification. Conclusion: Treatment of infrabony periodontal defects in patients with G-AgP with ABM/P-15 and GTR significantly improved clinical outcomes. The use of ABM/P-15 promoted a better radiographic bone fill.

ASSUNTO(S)

cell binding peptide p-15 guided tissue regeneration bone regeneration matriz óssea bovina inorgânica associada ao peptídeo de adesão celular periodontal diseases/surgery transplantation/heterologous membranes enxerto ósseo periodontite agressiva regeneração periodontal

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