Treatment of chronic urinary tract infections with gentamicin
AUTOR(ES)
Lindberg, A. A.
RESUMO
Gentamicin was of value in the treatment of chronic urinary tract infections caused by multiresistant bacterial strains for which no atoxic antibiotic was available. The treatment was carried out after alkalinization of the patient's urine. With the dosage given, gentamicin gave a low serum and a relatively high urine concentration. Excretion of active gentamicin in the urine was high even in patients with impaired renal function. The results of treatment of complicated chronic urinary tract infections with initial gentamicin and following long-term therapy showed negative urinary cultures in 12 out of 24 patients within one to 14 months of follow-up time. To reduce the risk of toxic side effects the dosage was adjusted according to the patient's kidney function. No development of resistance was demonstrated in the bacteria.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=473567Documentos Relacionados
- Comparison of moxalactam and gentamicin in the treatment of complicated urinary tract infections.
- Carumonam (Ro 17-2301; AMA-1080) compared with gentamicin for treatment of complicated urinary tract infections.
- Gentamicin and Gentamicin C1 in the Treatment of Complicated Urinary Tract Infections: Comparative Study of Efficacy, Tolerance, and Pharmacokinetics
- Treatment of complicated urinary tract infections with lomefloxacin compared with that with trimethoprim-sulfamethoxazole.
- Treatment of urinary tract infections with a combination of amoxicillin and clavulanic acid.
