Transtorno de déficit de atenção/hiperatividade e epilepsia: eficácia e segurança do metilfenidato em crianças e adolescentes com crises epilépticas não controladas / Attention deficit/hyperactivity disorder and epilepsy: efficacy and safety of the methylphenidate in children and adolescents with uncontrolled epilepsy
AUTOR(ES)
Júlio Amaro de Sá Koneski
DATA DE PUBLICAÇÃO
2010
RESUMO
INTRODUCTION: Attention Deficit and Hyperactivity Disorder (ADHD) is observed in 30 to 40 % children and adolescents with epilepsy. Recent studies demonstrate the safety of methylphenidate (MPH) in patients with controlled epilepsy. There is a lack of studies of patients with uncontrolled epilepsy. OBJECTIVE: to study the efficacy and safety of MPH in children and adolescents diagnosed with ADHD and uncontrolled epilepsy. METHODS: We evaluated 24 patients with ages of 7 and 16 years, diagnosed with epilepsy and ADHD, outpacient speciality clinic which took place in the Ambulatório de Especialidades of the Universidade da Região de Joinville (Univille). Inclusions criterias: at least two seizures in the previous 6 months; the diagnosis of ADHD based on DSM-IV criteria. RESULTS: The results of 24 patients have been evaluated, classified according to subtype ADHD as the following: 41.7 % inattentive type, 37.5 % combined and 20.8% hyperactive/impulsive type. The sample was distributed as the following: parcial epilepsy 58.3 % and generalized epilepsy 41.7 %. An average dose of MPH was 0.52 mg/kg/daily (22.3 mg daily). This was given for a period of 6 months to all patients. In 70.8 % the patients showed signs of improvement from ADHD symptoms and there was not increase of frequency of epileptic seizure in 22 of the 24 patients (91.6%). CONCLUSIONS: MPH was effective in the treatment of ADHD in patients with uncontrolled epilepsy. In the first 6 months of this study there was no increase of epileptic seizures.
ASSUNTO(S)
comorbidades attention deficit and hyperactivity disorder metilfenidato transtorno da falta de atenção com heperatividade epilepsy methylphenidate epilepsia comorbidities
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