Transport by the lactose permease of Escherichia coli as the basis of lactose killing.
AUTOR(ES)
Dykhuizen, D
RESUMO
Lactose killing is a peculiar phenomenon in which 80 to 98% of the Escherichia coli cells taken from a lactose-limited chemostat die when plated on standard lactose minimal media. This unique form of suicide is caused by the action of the lactose permease. Since uptake of either lactose or galactose by the lactose permease caused death, the action of rapid transport across the membrane must be the cause of the phenomenon. Alternative causes of lactose killing, such as accumulation of toxic metabolic intermediates or action of the beta-galactosidase, have been eliminated. It is proposed that rapid uptake of sugars by the lactose permease disrupts membrane function, perhaps causing collapse of the membrane potential.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=222459Documentos Relacionados
- Unraveling the mechanism of the lactose permease of Escherichia coli
- Sucrose transport by the Escherichia coli lactose carrier.
- Lactose permease of Escherichia coli catalyzes active beta-galactoside transport in a gram-positive bacterium.
- Arg-302 facilitates deprotonation of Glu-325 in the transport mechanism of the lactose permease from Escherichia coli
- A molecular mechanism for energy coupling in a membrane transport protein, the lactose permease of Escherichia coli