Translational Mini-Review Series on Vaccines for HIV: Harnessing innate immunity for HIV vaccine development

AUTOR(ES)

Rhee, E G

FONTE

Blackwell Science Inc

RESUMO

Innate immunity is critical for shaping vaccine-elicited adaptive immune responses. Several classes of immune sensors, including Toll-like receptors, retinoic acid-inducible gene-I-like receptors, nucleotide-binding oligomerization domain-like receptors and cytosolic DNA receptors mediate important innate immune pathways and provide potential targets for novel adjuvant development. Understanding how innate immunity modulates adaptive immune responses will probably be important for optimizing vaccine candidates. Here, we review recent advances in innate immunity, focusing upon their potential applications in developing adjuvants and vectors for HIV vaccines.

Documentos Relacionados

• Translational Mini-Review Series on Vaccines for HIV: T lymphocyte trafficking and vaccine-elicited mucosal immunity
• Translational Mini-Review Series on Immunology of Vascular Disease: Accelerated atherosclerosis in vasculitis
• Translational Mini-Review Series on B Cell-Directed Therapies: B cell-directed therapy for autoimmune diseases
• Translational Mini-Review Series on B Cell-Directed Therapies: Recent advances in B cell-directed biological therapies for autoimmune disorders
• Translational Mini-Review Series on Immunology of Vascular Disease: Inflammation, infections and Toll-like receptors in cardiovascular disease