Transgenic mice carrying the mouse mammary tumor virus ras fusion gene: distinct effects in various tissues.
AUTOR(ES)
Tremblay, P J
RESUMO
Transgenic mice carrying the v-Ha-ras oncogene under the control of the mouse mammary tumor virus long terminal repeat were produced. These mice exhibit several phenotypes: mammary tumors, bilateral hyperplasia of the harderian lacrimal gland, primary bronchio-alveolar lung adenocarcinoma, and splenomegaly. High levels of the transgene RNA were detected in mammary, harderian, and lung tumors. Accumulation of cells of the myeloid lineages was found in enlarged spleens. This phenotype may represent an indirect effect of v-Ha-ras expression on myeloid progenitors. Our data illustrate the cell-specific effects of v-Ha-ras.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=362668Documentos Relacionados
- Dietary lipids and calorie restriction affect mammary tumor incidence and gene expression in mouse mammary tumor virus/v-Ha-ras transgenic mice.
- Mouse mammary tumor virus: specific methylation patterns of proviral DNA in normal mouse tissues.
- Expression pattern of mouse mammary tumor virus in transgenic mice carrying exogenous proviruses of different origins.
- Prostate and mammary adenocarcinoma in transgenic mice carrying a rat C3(1) simian virus 40 large tumor antigen fusion gene.
- Mouse Mammary Tumor Virus c-rel Transgenic Mice Develop Mammary Tumors
