Transforming growth factor alpha inhibits secretion of gastric acid.
AUTOR(ES)
Rhodes, J A
RESUMO
Transforming growth factor alpha (TGF-alpha), a protein secreted by transformed cells and related to epidermal growth factor (EGF), was tested for its effects on gastric acid secretion. Guinea pig gastric mucosae were mounted in Ussing chambers and the rate of acid release was monitored by the pH-stat method. When administered prior to the secretagogue, TGF-alpha prevented the histamine-induced increase in the rate of acid secretion. Similarly, TGF-alpha caused a decrease in the rate of acid release in tissues that had already been stimulated with histamine. These data show that TGF-alpha inhibits gastric acid secretion in a manner similar to EGF and that the two growth factors share at least one physiological action unrelated to their mitogenic properties.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=323620Documentos Relacionados
- Localization of transforming growth factor alpha and its receptor in gastric mucosal cells. Implications for a regulatory role in acid secretion and mucosal renewal.
- Opposite effects of transforming growth factor alpha and epidermal growth factor on mouse placental lactogen I secretion.
- Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro.
- Transforming growth factor alpha protection against drug-induced injury to the rat gastric mucosa in vivo.
- Inhibition of Mycobacterium bovis BCG-Induced Tumor Necrosis Factor Alpha Secretion in Human Cells by Transforming Growth Factor β