Toxina distensora citoletal (CDT): Análise da resposta imune humoral em soros de pacientes com diferentes condições periodontais e seu efeito sobre a atividade macrofágica. / Cytolethal distending toxin (CDT): analysis of humoral immunity response in sera of patients with different periodontal conditions and the effect on macrophage activity.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

Aggregatibacter actinomycetemcomitans is associated with aggressive periodontitis and produces CDT. Aiming to contribute in the understanding the CDT activity in the immune response regulation, its action on macrophages was determined and the response against the toxin analyzed. CDT inhibited the proliferation of OBA-9 epithelial cells and Raw 264.7 macrophages and also inhibited the NO production by Raw 264.7 cells and peritoneal macrophages of C3H/HePas and C3H/HeJ mice, however, stimulated the IL-12 production. In the humoral immunity, 75% of sera from LAgP subjects and 81.8% were reactive to A. actinomycetemcomitans. There was not difference in the response against CDTA and CDTB among sera of patients with different periodontal conditions. All GAgP subjects were sera-reactivity to CDTC, however only 8.3% LAgP subjects, none in CP and 25% of healthy subjects were positive. CDT has immunomodulatory activity and the humoral response differ among bacteria infected subjects.

ASSUNTO(S)

igg il-10 macrophages interleukins Óxido nítrico interleucinas toxina distensora citoletal macrófagos aggregatibacter actinomycetemcomitans microbiology aggregatibacter actinomycetemcomitans nitric oxide il-10 cytolethal distending toxin immunoglobulins igg imunoglobulinas microbiologia

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