Towards in vivo application of RNA interference – new toys, old problems
AUTOR(ES)
Rutz, Sascha
FONTE
BioMed Central
RESUMO
RNA interference (RNAi) is the sequence-specific degradation of mRNA by short double-stranded RNA molecules. The technology, introduced only 5 years ago, has stimulated many fantasies regarding the future of functional gene analysis and gene therapy. Given its ease of application, its high efficiency and remarkable specificity, RNAi holds great promise for broad in vitro and in vivo application in all areas of biomedicine. Despite its potential, the major obstacle to the use of RNAi (as for all previous gene silencing approaches) is the need for efficient and sustained delivery of small interfering RNA into primary mammalian cells, and specific targeting of particular cell types in vivo.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=400443Documentos Relacionados
- Tuberculosis: Old problems and new approaches
- The lung in paracoccidioidomycosis: new insights into old problems
- Genetic aspects of birth defects: new understandings of old problems
- In vitro differentiation of murine embryonic stem cells. New approaches to old problems.
- EVERSION ENDARTERECTOMY: A NEW APPLICATION OF AN OLD TECHNIQUE