Tolerance: Of mice and men

AUTOR(ES)

Sachs, David H.

FONTE

American Society for Clinical Investigation

RESUMO

Little is known about the effect of an individual’s immune history on his or her response to an allogeneic tissue transplant. An important study now reveals that individuals harboring virally-induced memory T cells that are cross reactive with donor alloantigen are resistant to conventional strategies designed to induce transplant tolerance.

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