Thymus involution in alloxan diabetes: analysis of mast cells
AUTOR(ES)
Barreto, EO, Riederer, I, Arantes, ACS, Carvalho, VF, Farias-Filho, FA, Cordeiro, RSB, Martins, MA, Savino, W, e Silva, PMR
FONTE
Memórias do Instituto Oswaldo Cruz
DATA DE PUBLICAÇÃO
2005-03
RESUMO
We previously reported that alloxan-induced diabetes results in reduction in the number and reactivity of mast cells at different body sites. In this study, the influence of diabetes on thymic mast cells was investigated. Thymuses from diabetic rats showed marked alterations including shrinkage, thymocyte depletion, and increase in the extracellular matrix network, as compared to those profiles seen in normal animals. Nevertheless, we noted that the number and reactivity of mast cells remained unchanged. These findings indicate that although diabetes leads to critical alterations in the thymus, the local mast cell population is refractory to its effect. This suggests that thymic mast cells are under a different regulation as compared to those located in other tissues.
Documentos Relacionados
- Mast cell changes in experimental diabetes: focus on attenuation of allergic events
- Study of the determining mechanisms of the hyporeactivity of mast cells in diabetes experimental induced for alloxan in rats.
- A role of Hsp60 in autoimmune diabetes: analysis in a transgenic model.
- The effect of metabolic surgery on type 1 diabetes: meta-analysis
- Thymus involution induced by mouse hepatitis virus A59 in BALB/c mice.