Thymus-Dependent Lymphocytes of Peripheral Blood in Leprosy Patients
AUTOR(ES)
Lim, Soo-Duk
RESUMO
Study of the numbers of thymus-derived lymphocytes by the rosette assay (T-RFC) in patients with leprosy reveals that lower than normal numbers of T-RFC are regularly seen in those patients with the active lepromatous form of this disease. Essentially normal numbers of T-RFC were found in inactive lepromatous, borderline, and indeterminate types of leprosy. The lowest percentages and lowest absolute numbers of T-RFC were encountered in patients with lepromatous leprosy resistant to chemotherapy. Patients with lepromatous leprosy complicated by erythema nodosum leprosum show numbers of T-RFC that are more nearly normal than the numbers of T-RFC in patients with uncomplicated lepromatous leprosy. These findings are discussed with respect to the pathogenesis of lepromatous leprosy and the T-RFC deficiency demonstrated in this disease. The possibility that transient defects in T-RFC numbers or function may predispose to lepromatous leprosy is proposed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=414815Documentos Relacionados
- Thymus-dependent lymphocytes in human bone marrow.
- Neutropenia in three patients with rheumatic disorders. Suppression of granulopoiesis by control-sensitive thymus-dependent lymphocytes.
- Depressed antibody responses to a thymus-dependent antigen in toxoplasmosis.
- Direct demonstration of murine thymus-dependent cell surface endogenous immunoglobin.
- Thymus-dependent control of host defense mechanisms against Trypanosoma cruzi infection.