Thienamycin: New Beta-Lactam Antibiotic with Potent Broad-Spectrum Activity

AUTOR(ES)

Weaver, Susanne S.

RESUMO

Thienamycin, a new beta-lactam antibiotic, exhibited potent, broad-spectrum activity in vitro against gram-negative bacilli and gram-positive cocci, including many isolates resistant to currently available antibiotics. All isolates were inhibited at concentrations less than or equal to 25 μg/ml, with the exception of 12% of isolates of Enterobacter spp. and 3% of isolates of Serratia marcescens. Its activity decreased with an increase in inoculum concentration of from 105 to 107 cells per ml.

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