There is no evident correlation between interleukin-10 gene polymorphisms and periportal fibrosis regression after specific treatment
AUTOR(ES)
Silva, Paula Carolina Valença, Silva, Aline Vieira da, Silva, Taysa Nascimento, Vasconcelos, Letícia Moura de, Gomes, Adriana Vieira, Coêlho, Maria Rosângela Cunha Duarte, Muniz, Maria Tereza Cartaxo, Domingues, Ana Lúcia Coutinho
FONTE
Rev. Soc. Bras. Med. Trop.
DATA DE PUBLICAÇÃO
2016-12
RESUMO
Abstract INTRODUCTION: We evaluated the associations between interleukin-10 (IL-10) gene polymorphisms -G1082A/-C819T/-C592A and periportal fibrosis regression after specific treatment for schistosomiasis. METHODS: This retrospective cohort study involved 125 Brazilian patients infected with Schistosomiasis mansoni, who were followed up for 2 years after specific treatment to estimate the probability of periportal fibrosis regression. RESULTS: There was no evidence of associations between IL-10 polymorphisms and periportal fibrosis regression after treatment. CONCLUSIONS: There was no evidence of associations between gene promoter polymorphisms of IL-10 and the regression of periportal fibrosis in this Brazilian population.
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