Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing
AUTOR(ES)
Sazani, Peter
FONTE
American Society for Clinical Investigation
RESUMO
An estimated 60% of all human genes undergo alternative splicing, a highly regulated process that produces splice variants with different functions. Such variants have been linked to a variety of cancers, and genetic diseases such as thalassemia and cystic fibrosis. This Perspective describes a promising approach to RNA repair based on the use of antisense oligonucleotides to modulate alternative splicing and engender the production of therapeutic gene products.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=171400Documentos Relacionados
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