The zeste-white interaction: induction and genetic analysis of a novel class of zeste alleles

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RESUMO

The recovery and analysis of a novel class of zeste mutations is described. zop6 and zop11 do not require two w+ genes for their expression unless the z+ gene is present. Analysis of genetic interactions among zeste alleles proved that zop mutations are strong antagonists of the z+ gene product. zop6 is readily reverted by X-rays or by ethylmethane sulphonate to a range of intermediate zeste alleles and thus it is considered to be an insertional mutation. We suggest that z1 and op mutations arose as a result of insertions in a presumptive control region, and two alternative models for the structure of the zeste locus are evaluated.

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