The use of monoclonal antibody (Rituximab) in the treatment of type II mixed cryoglobulinemia
AUTOR(ES)
Rego, Thiago Carlos Gonçalves, Massumoto, Celso Mitsushi, Batista, Rodrigo Siqueira, Moura, Larissa Hanauer de, Soares, Lygia Maria Costa, Gomes, Andréia Patrícia
FONTE
Brazilian Journal of Infectious Diseases
DATA DE PUBLICAÇÃO
2007-02
RESUMO
Anti-CD20 monoclonal antibody has been successfully used to treat several self-immune diseases. The authors report the case of a 71 year-old female patient under the use of pegylated form of interferon á associated with ribavirin for the treatment of hepatitis C, who, after concluding the therapeutic program - negative Polymerase Chain Reaction (PCR) - developed a severe cutaneous vasculitis, receiving the diagnostic of type II mixed cryoglobulinemia. Four sessions of plasmapheresis were prescribed along the period of 11 days, with no result. The choice made was to administer anti-CD 20 monoclonal antibody (rituximab), 375 mg/m², per week, during four consecutive weeks. One could observe fast recovery from the purpura, as well as total remission of urticaria.
Documentos Relacionados
- Serum Interferon (IFN)-Neutralizing Antibodies and Bioactivities of IFNs in Patients with Severe Type II Essential Mixed Cryoglobulinemia
- Estudo da conjugação e radiomarcação do anticorpo monoclonal rituximab para aplicação em terapia radionuclídica
- Use of rituximab in two unusual antibody-mediated autoimmune disorders
- Use of rituximab in glomerulopathies
- Purification of Chlamydia trachomatis strains in mixed infection by monoclonal antibody neutralization.