The use of iodotrimethylsilane in nucleosidation procedure.

AUTOR(ES)

Tocik, Z

RESUMO

1-O-Acetyl-2,3,5-tri-O-benzoyl-beta-D-ribofuranose (I) was reacted with iodotrimethylsilane (II) and the product, the glycosyl iodide, was coupled with silylated uracil to afford 1-(2,3,5-tri-O-benzoyl-beta-D-ribofuranosyl)uracil (III; 89%), with silyated cytosine to afford, on subsequent acetylation, 1-(2,3,5-tri-O-benzoyl-beta-0D-ribofuranosyl)-4-acetamido-2-(1H)-pyrimidinone (IVb; 81%), and with chloromercuri-N-benzoyl-adenine to afford Va and on subsequent debenzoylation, adenosine (Vb; 49%).

Documentos Relacionados

• Cost and outcome of the Whipple procedure.
• Continuing evolution of the pelvic pouch procedure.
• The use of large-fragment DNA polymerase I improves the DNAse dependence of the in situ nick-translation procedure.
• Intraocular lens power calculations in the triple procedure.
• Detection of high levels of polyadenylate-containing RNA in bacteria by the use of a single-step RNA isolation procedure.