The SL autoantibody-antigen system: clinical and biochemical studies.
AUTOR(ES)
Bernstein, R M
RESUMO
A recently described autoantibody, SL, was found in serum from 27 patients with autoimmune disease, including 20 with systemic lupus erythematosus (SLE) where the frequently was 7%. Analysis of clinical, serological, and HLA data from 119 SLE patients showed no positive associations with anti-SL antibody apart from a higher frequency of non-infective fever. Most SL positive sera contained other precipitins, notably antibodies to Ro(SS-A) and the proliferating cell nuclear antigen, PCNA. Anti-SL IgG recognised a protein of 32 000 daltons without associated RNA. This polypeptide was distinguished from a similarly sized component of the Sm and RNP ribonucleoprotein particles by demonstrating different products of partial proteolysis. Although anti-SL antibody is of limited clinical importance, it occurs with twice the frequency of anti-SM antibody in white patients with SLE. Preliminary studies indicate that SL and the Japanese Ki system are identical.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1001891Documentos Relacionados
- Osteoporosis-pseudoglioma syndrome: clinical, morphological, and biochemical studies.
- Dynorphin immunocytochemical localization in brain and peripheral nervous system: preliminary studies.
- Opioids in the immune system: from experimental studies to clinical practice
- X-Y translocation in a retarded phenotypic male. Clinical, cytogenetic, biochemical, and serogenetic studies.
- Four cases of late onset metachromatic leucodystrophy in a family: clinical, biochemical and neuropathological studies.