The skin homing receptor cutaneous leucocyte-associated antigen (CLA) is up-regulated by Leishmania antigens in T lymphocytes during active cutaneous leishmaniasis

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Blackwell Science Inc

RESUMO

The cutaneous leucocyte-associated antigen receptor (CLA) can direct Leishmania-specific T lymphocytes towards inflamed skin lesions. Homing receptors [CLA, lymphocyte-associated antigen 1 (LFA-1) or CD62L] were analysed in lymphocytes from blood and cutaneous leishmaniasis (CL) lesions. CL patients with active lesions (A-CL) presented lower levels of T lymphocytes expressing the CLA+ phenotype (T CD4+ = 10·4% ± 7·5% and T CD8+ = 5·8% ± 3·4%) than did healthy subjects (HS) (T CD4+ = 19·3% ± 13·1% and T CD8+ = 21·6% ± 8·8%), notably in T CD8+ (P < 0·001). In clinically cured patients these percentages returned to levels observed in HS. Leishmanial antigens up-regulated CLA in T cells (CLA+ in T CD4+ = 33·3% ± 14·1%; CLA+ in T CD8+ = 22·4% ± 9·4%) from A-CL but not from HS. An enrichment of CLA+ cells was observed in lesions (CLA+ in T CD4+ = 45·9% ± 22·5%; CLA+ in T CD8+ = 46·4% ± 16·1%) in comparison with blood (CLA+ in T CD4+ = 10·4% ± 7·5%; CLA+ in T CD8+ = 5·8% ± 3·4%). Conversely, LFA-1 was highly expressed in CD8+ T cells and augmented in CD4+ T from peripheral blood of A-CL patients. In contrast, CD62L was not affected. These results suggest that Leishmania antigens can modulate molecules responsible for migration to skin lesions, potentially influencing the cell composition of inflammatory infiltrate of leishmaniasis or even the severity of the disease.

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