The Role of the Immune System on the Cardiac Complications Observed in SARS-CoV-2

AUTOR(ES)

Vigário, Larissa Carvalho; Muradas, Guilherme; Paiva, Claudia Neto; Medei, Emiliano

FONTE

International Journal of Cardiovascular Sciences

DATA DE PUBLICAÇÃO

2022

RESUMO

Abstract An acute respiratory syndrome caused by SARS-CoV2 was declared a pandemic by the World Health Organization. Current data in the world and in Brazil show that approximately 40% of patients who died have some type of cardiac comorbidity. There are also robust reports showing an increase in IL-6 / IL-1B / TNF-alpha and the presence of lymphopenia in patients with COVID-19. Our team and others have shown that increased cytokines are the link between arrhythmias/Left ventricular dysfunction and the immune system in different diseases. In addition, it has been well demonstrated that lymphopenia can not only be a good marker, but also a factor that causes heart failure. Thus, the present review focused on the role of the immune system upon the cardiac alterations observed in the SARS-CoV2 infection. Additionally, it was well described that SARS-CoV-2 is able to infect cardiac cells. Therefore, here it will be reviewed in deep.

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