The role of statins as potential targets for bone formation

AUTOR(ES)

Garrett, I Ross

FONTE

BioMed Central

RESUMO

Inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A reductase enzyme have recently been shown to stimulate bone formation in rodents both in vitro and in vivo. In bone cells, these inhibitors increase the gene expression of bone morphogenetic protein-2, which is an autocrine-paracrine factor for osteoblast differentiation.

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